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This family comprises only one protein, SET7/9, which mono-methylates histone at H3K4 92 KMT7 was found to methylate, besides histone, numerous non-histone proteins, including p53, DNA methyltransferase 1 (DNMT1), lawyer article estrogen receptor alpha (ERα), nuclear issue kappaB (NFκB), and parts of the TATA binding protein (TBP) advanced, TBP-associated components TAF10 and TAF7 ninety three The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Okay/R-S/T-Ok (goal lysine is bold), can also be acknowledged by the H3K4 demethylase KDM1A/LSD1, which is capable of eradicating the methyl mark on most of these substrates 17 , 94 Due to this fact KMT7/KDM1A has emerged as a classic model for lawyer article dynamic lysine methylation of each histone and non-histone proteins.

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